Diego Luna
Manolo (voice)
Channing Tatum
Joaquin (voice)
Zoe Saldaña
Maria (voice)
Christina Applegate
Mary Beth (voice)
Eugenio Derbez
Chato (voice)
Cheech Marin
Pancho Rodriguez (voice)
Gabriel Iglesias
Pepe Rodriguez (voice)
Ron Perlman
Xibalba (voice)
Kate del Castillo
La Muerte (voice)
Ana de la Reguera
Carmen Sánchez (voice)
Dan Navarro
Chakal (voice)
Ice Cube
Candle Maker (voice)
Hector Elizondo
Carlos Sanchez (voice)
Danny Trejo
Skeleton Luis (voice)
Carlos Alazraqui
General Posada / Dali / Chuy (voice)
Elijah Rodriguez
Young Joaquin
Plácido Domingo
Skeleton Jorge (voice)
Grey DeLisle
Grandmother (voice) (as Grey Griffin)
Miguel Sandoval
Land of the Remembered Captain (voice)
Ben Gleib
Goya / Dali (voice)
Jorge R. Gutierrez
Skeleton Carmelo (voice)
Anjelah Johnson-Reyes
Adelita / Nina (voice)
Sandra Equihua
Scardelita (voice)
Gunnar Sizemore
Ignacio (voice)
Angélica María
Sister Ana (voice)
Eric Bauza
Father Domingo / Cave Guardian (voice)
Aron Warner
Thomas (voice)
Sandra Echeverría
Claudia (voice)
Tonita Castro
La Muerte as Old Woman (voice)
Troy Evans
Old Man Hemingway (voice)
Guillermo del Toro
Land of the Remembered Captain's Wife (voice)
Brad Booker
Conductor (voice)
Rosemary Alexander
Additional Voices (voice)
Eva Bella
Additional Voices (voice)
Vicki Davis
Additional Voices (voice)
Moosie Drier
Additional Voices (voice)
Cullen McCarthy
Additional Voices (voice)
David Michie
Additional Voices (voice)
Jonathan Nichols
Additional Voices (voice)
Al Rodrigo
Additional Voices (voice)
Marcelo Tubert
Additional Voices (voice)
Lynnanne Zager
Additional Voices (voice)
Ruth Zalduondo
Additional Voices (voice)
Newell Alexander
Additional Voices (voice)
Jose Alvarez
Additional Voices (voice)
David Cowgill
Additional Voices (voice)
Elisa Gabrielli
Additional Voices (voice)
Richard Miro
Additional Voices (voice)
Arthur Ortiz
Additional Voices (voice)
Joe Matthews
Young Manolo (singer)
Emil-Bastien Bouffard
Young Manolo (voice)
Genesis Ochoa
Young Maria (voice)
Trey Bumpass
Goth Kid / Orphan
Ricardo El Mandril Sanchez
Pablo Rodriguez (voice)
Ishan Sharma
Sanjay
Kennedy Peil
Sasha (voice)
Callahan Clark
Jane (voice)
Steve Alterman
Additional Voices (voice)
Madison Carlon
Additional Voices (voice)
Michelle Moores
Additional Voices (voice)
Nathaniel Semsen
Additional Voices (voice)
