Keanu Reeves
Thomas "Neo" Anderson (voice)
Carrie-Anne Moss
Trinity (voice)
Clayton Watson
The Kid (voice)
Pamela Adlon
Jue ("Final Flight of the Osiris") / Manabu ("Beyond") (voice)
Melinda Clarke
Alexa ("Matriculated") (voice)
John DiMaggio
Crew Man ("Final Flight of the Osiris") / Kaiser ("Program") (voice)
Kevin Michael Richardson
Thadeus ("Final Flight of Osiris") / Cop ("Kid's Story") / Agent #2 ("World Record")
Tom Kenny
Operator ("Final Flight of Osiris")
Rick Gomez
Pilot ("Final Flight of Osiris")
Tara Strong
Crew Woman ("Final Flight of Osiris") / Nurse ("World Record") / Misha ("Beyond")
Bette Ford
Old Woman ("Final Flight of Osiris")
Debi Derryberry
Kid ("The Second Renaissance Part I & II")
Jill Talley
Mother ("The Second Renaissance Part I & II")
Dwight Schultz
Additional Voices ("The Second Renaissance Part I & II") / Monaka ("Matriculated")
James Arnold Taylor
Additional Voices ("The Second Renaissance Part I & II") / Ash ("A Detective Story") / Raul ("Matriculated")
John DeMita
Teacher ("Kid's Story")
Hedy Burress
Cis ("Program") / Yoko ("Beyond")
Phil LaMarr
Duo ("Program")
Victor Williams
Dan ("World Record")
John Wesley
Dan's Dad ("World Record")
Alex Fernandez
Tom ("World Record")
Allison Smith
Reporter ("World Record")
Matt McKenzie
Agent #1 ("World Record") / Agent ("Beyond") / Agent ("A Detective Story")
Tress MacNeille
Housewife ("Beyond") / Kenny ("Beyond")
Kath Soucie
Pudgy ("Beyond") / Masa ("Beyond") / Sara ("Beyond")
Terrence 'T.C.' Carson
Clarence ("A Detective Story")
Rodney Saulsberry
Chyron ("Matriculated")
Olivia d'Abo
Rox ("Matriculated")
Jack Fletcher
Sandro ("Matriculated")
Akio Otsuka
Thadeus (voice)
Julia Fletcher
The Instructor ("The Second Renaissance Part I & II") / Narrator ("World Record")
Dane A. Davis
01 Versatran Spokesman ("The Second Renaissance Part I & II")
