Lea Thompson
Beverly Switzler
Jeffrey Jones
Dr. Walter Jenning
Tim Robbins
Phil Blumburtt
Ed Gale
Howard T. Duck
Chip Zien
Howard T. Duck (voice)
Tim Rose
Howard T. Duck
Jordan Prentice
Howard T. Duck
Paul Guilfoyle
Lieutenant Welker
Liz Sagal
Ronette
Dominique Davalos
Cal
Holly Robinson Peete
K.C.
Tommy Swerdlow
Ginger Moss
Richard Edson
Ritchie
Miles Chapin
Carter
Richard McGonagle
First Cop
Virginia Capers
Coramae
Debbie Lee Carrington
Additional Ducks (voice)
Miguel Sandoval
Club Owner
Sheldon Feldner
Hot Tub Spa Owner
Paul Comi
Dr. Chapin
James Lashly
State Trooper
David Paymer
Larry, Scientist
William Hall
Hanson
Gary Littlejohn
Third Trucker
Thomas Dolby
Bartender in Rock Club
Kristopher Logan
Punk
John Fleck
Pimples
Nancy Fish
Bag Lady
Wood Moy
Chef
Richard Kiley
The Cosmos (voice)
Mel Blanc
Daffy Duck (voice)
Steve Sleap
Howard T. Duck
Peter Baird
Howard T. Duck
Mary Wells
Howard T. Duck
Lisa Sturz
Howard T. Duck
Jorli McLain
Waitress
Lee Anthony
Grossbach
Maureen Coyne
Teacher
Tom Parker
Steve Kanelli
Ed Holmes
TV Duck Hunter
Denny Delk
Sergeant
Martin Ganapoler
First Trucker
Tom Rayhall
Second Trucker
Reed Kirk Rahlmann
Bender
William McCoy
Skin Head
Steven Kravitz
Lover Boy
Anne Tofflemire
Lover Girl
Marcia Banks
Mama Biker
Monty Hoffman
Club Bouncer
Ted Kurtz
Kirby
Wanda McCaddon
Hostess
James Brady
First Tour Guide
Carol McElheney
Screaming Woman
Jeanne Lauren
Bear