Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Bill Murray
Frank Detorre
Molly Shannon
Mrs. Boyd
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Sherry Lynn
(voice)
Mickie McGowan
Additional Character Voice (voice)
Chris Elliott
Bob
Elena Franklin
Shane Detorre
Kid Rock
Kidney Rock
Carlos Alazraqui
Additional Character Voices (voice)
Rodger Bumpass
Additional Character Voices (voice)
Richard Steven Horvitz
Additional Character Voices (voice)
Danny Mann
Additional Character Voices (voice)
Mickie McGowan
Additional Character Voices (voice)
Jonathan Adams
Additional Character Voices (voice)
Uncle Kracker
Kidney Rock (voice)
