Christine Cavanaugh
Charles 'Chuckie' Finster Jr. (voice)
Cheryl Chase
Angelica C. Pickles (voice)
Kath Soucie
Phillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice)
Tara Strong
Dylan Prescott 'Dil' Pickles (voice)
Cree Summer
Susan 'Susie' Carmichael (voice)
Tress MacNeille
Charlotte C. Pickles (voice)
Melanie Chartoff
Didi Pickles (voice)
Jack Riley
Stu Pickles (voice)
Joe Alaskey
Louis 'Grandpa' Pickles (voice)
Michael Bell
Drew Pickles/Charles 'Chaz' Finster, Sr. (voice)
Charlie Adler
Professor Spooky (voice)
Elizabeth Daily
Tommy Pickles (voice)
