Nathan Fillion
Malcolm "Mal" Reynolds
Summer Glau
River Tam
Gina Torres
Zoë Alleyne Washburne
Alan Tudyk
Hoban "Wash" Washburne
Morena Baccarin
Inara Serra
Adam Baldwin
Jayne Cobb
Jewel Staite
Kaywinnet Lee "Kaylee" Frye
Sean Maher
Simon Tam
Ron Glass
Shepherd Derrial Book
Chiwetel Ejiofor
The Operative
David Krumholtz
Mr. Universe
Michael Hitchcock
Dr. Mathias
Sarah Paulson
Dr. Caron
Yan Feldman
Mingojerry "Mingo" Rample
Nectar Rose
Lenore
Tamara Taylor
Teacher
Glenn Howerton
Lilac Young Tough
Hunter Ansley Wryn
Young River Tam
Marley McClean
Girl Student
Scott Kinworthy
Ensign
Erik Weiner
Helmsman
Peter James Smith
Lab Technician
Weston Nathanson
Trade Agent
Amy Wieczorek
Lilac Mom
Tristan Jarred
Lilac Son
Terrence Hardy Jr.
Mining Camp Boy
Ryan Tasz
Black Room Soldier
Colin Patrick Lynch
Black Room Soldier
Terrell Tilford
News Anchor
Linda Wang
Chinese Snake Dancer (uncredited)
Neil Patrick Harris
Screaming Reaver (uncredited)
Matt McColm
Lab Security (uncredited)
Marcus Young
Bar Security (uncredited)
Dennis Keiffer
Bar Guy (uncredited)
Rafael Feldman
Fantastic "Fanty" Rample
Logan O'Brien
Boy Student
Erik Erotas
Boy Student
Demetra Raven
Girl Student
Jessica Huang
Girl Student
Conor O'Brien
Lab Technician
Carrie "CeCe" Cline
Young Female Intern
Chuck O'Neil
Vault Guard
Elaine Mani Lee
Fan Dancer
Brian O'Hare
Alliance Pilot
Joshua Michael Kwiat
Slovenly Beaumonde Man
Antonio Rufino
Bartender (uncredited)
Rick Williamson
Bar Guy (uncredited)